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Patent
Document Number 1338682 :
BIOLOGICALLY ACTIVE UNDENATURED WHEY PROTEIN CONCENTRATE AS FOOD
SUPPLEMENT
CONCENTRE DE PROTEINE NON CASEIQUE, BIOLOGIQUEMENT ACTIF, UTILE
COMME SUPPLEMENT ALIMENTAIRE
CLAIMS:
THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE PROPERTY OR
PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A whey protein composition comprising a substantially
undenatured whey
protein concentrate obtained from bovine, goat or sheep milk and
containing substantially all the whey protein present in the raw
milk, Vitamin B1 in an amount of at least 1.5 mg. B per 100 grams
of whey protein and Vitamin B2 of at least 1.5 mg B per 100 grams
of whey protein.
2. A composition as in claim 1 in which Vitamin B1 is in the range
1.5 to 2.0
mg per 100 g. of whey protein.
3. A composition as in claim 1 in which Vitamin B2 is in the range
1.5 to
2.0
mg per 100 g of whey protein.
4. A composition as in claim 1 which is free of lactose.
5. A composition as in claim 1 having immunoenhancing properties
that are
heat labile, insensitive to pancreatic digestion and dependent
upon the undenatured state.
6. A method for producing a substantially undenatured whey protein
concentrate from milk without the use of temperatures of
pasteurization comprising:
a) precipitating curd;
b) separating whey from the curd,
c) irradiating the whey with a radiation dose in the range 5-15
kGy to
give an antibacterial effect equivalent to conventional
pasteurization, the foregoing steps being conducted without
heating the whey and any agitation being slow to minimize protein
denaturation,
d) concentrating the whey and subjecting it to ultrafiltration to
separate a whey protein concentrate as a retentate from lactose,
salts and water.
7. A method for producing a substantially undenatured whey protein
concentrate from milk without the use of temperatures of
pasteurization comprising:
a) precipitating curd;
b) separating whey from the curd;
c) optionally irradiating the whey with a radiation dose in the
range 5
15 kGy to give an antibacterial effect equivalent to conventional
pasteurization, the foregoing steps being conducted without
heating the whey and any agitation being slow to minimize protein
denaturation, and
d) concentrating the whey and subjecting it to ultrafiltration to
separate a whey protein concentrate as a retentate from lactose,
salts and water.
8. A method as in claim 7, in which ultrafiltration is conducted
with a membrane having a molecular weight cut off selected so as
to retain protein components with the molecular weight over
10,000.
9. A method as in claim 7, in which the method is carried out at a
maximum
temperature of about 30°C.
10. A method as in claim 7, in which the ultrafiltration is
carried out at a
temperature in the range of 4° to 20°C.
11. A method as in claim 7, wherein the whey protein concentrate
comprises
two or more proteins of whey.
12. A method as in claim 7, wherein the whey protein concentrate
comprises a substantially undenatured whey protein isolate mixture
containing bovine serum albumin, alpha-lactalbumin and lactoferrin
proteins, which are cystine rich, said bovine serum albumin, and
lactoferrin also being rich in glutamyl cysteine, in an amount
effective to replenish depleted cellular glutathione and enhance
the immune response.
13. A method as in claim 7, wherein the whey protein concentrate
comprises a substantially undenatured whey protein isolate mixture
which is cystine rich and rich in glutamyl cysteine, in an amount
effective to replenish depleted cellular glutathione and enhance
the immune response.
14. The method according to claim 7, characterized in that the
whey protein
concentrate is produced by subjecting whey, a liquid whey protein
concentrate or a reconstituted whey protein concentrate powder to
ultrafiltration through a membrane having a molecular weight
cutoff selected so as to retain protein components with the
molecular weight over
10,000.
15. The use for improving the immune response in mammals as
measured by sheep red blood cell injection of a substantially
indenatured whey protein concentrate obtained from bovine, goat or
sheep milk and containing substantially all the whey protein
present in the raw milk, Vitamin B1 in an amount of at least 1.5
mg B1 per 100 grams of whey protein, and Vitamin B2 in an amount
of at least 1.5 mg per 100 grams of whey protein, and said Vitamin
B1 and B2 being present in amounts in excess of minimum daily
requirements.
16. A use as in claim 15, in which Vitamin B1 is in the range 1.5
to 2.0 mg per
100 g of whey protein.
17. A method as in claim 15, in which Vitamin B2 is in the range
1.5 to 2.0 mg
per 100 g of whey protein.
18. The use for improving the immune response in mammals as
measured by sheep red blood cells of a composition comprising
Vitamin B2 in an amount in excess of minimum daily requirements,
and a substantially undenatured whey protein containing
substantially all the whey protein present in the raw milk in an
amount sufficient substantially to satisfy the daily requirements
of protein of said mammal.
19. The use for improving the immune response of mammals as
measured by sheep red blood cells of an orally administrable
substantially undenatured whey protein concentrate obtained from
bovine, goat or sheep milk and containing substantially all the
whey protein present in the raw milk, said whey protein
concentrate having immunoenhancing properties that are heat
labile, insensitive to pancreatic digestion and dependent upon the
substantially undenatured state.
20. The use according to claim 15, wherein the minimum daily
requirement of
Vitamin B1 is 0.5-0.6 milligrams per 1000 calorie.
21. The use of claim 15, wherein the minimum daily requirement of
Vitamin
B2 is 1.2-1.5 milligrams per day.
22. The use of claim 15 in which said vitamin supplement comprises
Vitamins
B1 and B2 in amounts in excess of minimum daily requirements.
23. The use of claim 21, wherein the minimum daily requirement of
Vitamin
B1 is 0.5 milligrams per 1000 calorie and the minimum daily
requirement for Vitamin B2 is 0.5-0.6 milligrams per 1000 calorie
or 1.2-1.5 milligrams per day.
24. A dietary supplement for a mammal comprising, in combination,
Vitamins
B1 and B2 in amounts in excess of minimum daily requirements, for
that mammal, together with a therapeutically or prophylactically
effective amounts of substantially undenatured whey protein
concentrate having enhanced biological activity, wherein the
biological activity of the substantially undenatured whey protein
concentrate is based on the overall amino acid and associated
small peptides pattern resulting from the contribution of all its
peptides components.
25. A dietary supplement for a mammal comprising a substantially
undenatured whey protein concentrate having two or more proteins
of whey.
26. A dietary supplement for a mammal comprising a substantially
undenatured whey protein isolate mixture containing the bovine
serum albumin, alpha-lactalbumin and lactoferrin proteins, which
are cystine rich, said bovine serum albumin and lactoferrin also
being rich in glutamyl cysteine, in an amount effective to
replenish depleted cellular glutathione and enhance the immune
response.
27. A dietary supplement for a mammal comprising a substantially
undenatured whey protein isolate mixture which is cystine rich and
rich in glutamyl cysteine, in an amount effective to replenish
depleted cellular glutathione and enhance the immune response.
28. A dietary supplement having enhanced biological activity
comprising the
whey protein composition according to claim 1 in combination with
a neutral vehicle for oral feeding.
29. A dietary supplement having whey protein in an amount of about
18 to 28
grams of whey protein per 100 grams of diet.
30. An intensive care food having enhanced biological activity
(immunoenhancement)comprising the whey protein composition
according to claim 1 in combination with a neutral vehicle
suitable for oral feeding.
31. A pharmaceutical composition having enhanced biological
activity
comprising the whey protein composition according to claim 1 in
combination with a neutral carrier suitable for oral feeding.
32. A drug for mammals including humans containing a whey protein
composition according to claim 1.
33. A whey protein concentrate comprising cystine to act as a
precursor for
glutathione synthesis and including heat labile protein components
providing an amino acid and associated small peptide pattern
adapted significantly to enhance the bioavailability of the
cysteine thereby raising cell glutathione content and improving
humoral immune response.
34. A composition as in claim 33 to which Vitamin B2 has been
added.
35. A composition as in claim 33 to which Vitamin B1 has been
added.
36. A composition as in claim 33 to which has been added Vitamin
B1 has
been added.
37. A composition as in claim 33 to which has been added Vitamin
B1 in the
range 1.5 to 2.0 mg and Vitamin B2 in the range 1.5 to 2.0 mg per
100 grams of whey protein composition.
38. A whey protein composition as in claim 33, wherein the whey
protein
concentrate comprises a whey protein isolate mixture having two or
more proteins of whey.
39. A whey protein composition as in claim 33, wherein the whey
protein
concentrate comprises a substantially undenatured whey protein
isolate mixture which is cystine rich, also being rich in glutamyl
cysteine, in an amount effective to replenish depleted cellular
glutathione and enhance the immune response.
40. A whey protein composition comprising a substantially
undenatured whey
protein concentrate obtained from raw bovine, goat or sheep milk
which contains substantially all the heat labile whey protein
present in the raw milk, the whey protein being present in an
amount sufficient to provide an amount offrom about 18 to about 28
grams of whey protein per 100 grams of composition, Vitamin B1 in
an amount of at least 1.5 mg per 100 grams of composition and
Vitamin B2 in an amount of at least 1.5 mg per 100 grams of
composition.
41. The composition as in claim 40, wherein the amount of Vitamin
B1 is in the
range of from 1.5 mg to 2.0 mg per 100 g of composition.
42. The composition as in claim 40, wherein the amount of Vitamin
B2 is in the
range of from 1.5 mg to 2.0 mg per 100 g of composition.
43. The composition as in claim 40, wherein the composition is
free of lactose.
44. The composition as in claim 40 having immunoenhancing
properties that are heat labile, insensitive to pancreatic
digestion and dependent upon the undenatured state.
45. The composition as in any one of claims 33,38 or 39, wherein
the whey protein is present, in an amount sufficient to provide an
amount of from about 18 to about 28 grams of whey protein per 100
grams of composition.
46. The use for improving the immune response in mammals as
measured by sheep red blood cell injection of an orally
administrable substantially undensatured whey protein concentrate
obtained from bovine, goat or sheep milk containing substantially
all the heat labile whey protein present in the raw milk, the whey
protein being present in an amount sufficient to provide an amount
of from about 18 g to about 28 g of whey protein per 100 g of
composition, Vitamin B1 in an amount of at least 1.5 mg per 100
grams of composition and Vitamin B2 in an amount of at least 1.5
mg per 100 grams of composition, the Vitamin B, and Vitamin B2
being included in amounts in excess of minimum daily requirements.
47. The use as in claim 46, wherein the amount of Vitamin B1 is an
amount of
from 1.5 mg to 2.0 mg per 100 g of composition.
48. The use as in claim 46, wherein the amount of Vitamin B2 is an
amount of
from 1.5 mg to 2.0 mg per 100 g of composition.
49 . The use as in claim 46, wherein the minimum daily requirement
of Vitamin
B1 is 0.5-0.6 mg per 1000 calorie.
50 . The use as in claim 46, wherein the minimum daily requirement
of Vitamin
B2 is 1.2-1.5 mg per day.
51. The use as in claim 46, wherein the minimum daily requirement
of Vitamin
B1 is 0.5 milligrams per 1000 calorie and the minimum daily
requirement for Vitamin B2 is 0.5-0.6 milligrams per 1000 calorie
of 1.2-1.5 milligrams per day.
52. The use for improving the immune response in mammals as
measured by
sheep red blood cell injection of an orally administrable
composition comprising Vitamin B2 in an amount in excess of
minimum daily requirements, and a substantially undenatured whey
protein concentrate containing substantially all the heat labile
whey protein present in the raw milk in an amount sufficient to
supplement the daily requirements of protein of said mammal.
53. The use for improving the immune response of mammals as
measured by sheep red blood cells of an orally administrable
substantially undenatured whey protein concentrate obtained from
bovine, goat or sheep milk and containing substantially all the
whey protein present in the raw milk, said whey protein
concentrate having immunoenhancing properties that are heat
labile, insensitive to pancreatic digestion and dependent upon the
undenatured state and being present in an amount substantially
sufficient to supplement the daily requirements of protein of such
mammal.
54. A use of a whey protein concentrate in an amount effective to
increase cellular glutathione concentration.
55. A use as in claim 54, in which the whey protein concentrate
has a bovine serum albumin level of at least 9.5% of the whey
protein mixture.
56. A use as in claim 54, in which the whey protein concentrate
has a bovine serum albumin level of at least 7% or more of the
whey protein mixture.
57. The use for improving the immune response in mammals as
measured by sheep red blood cell injection of an orally
administrable substantially undenatured whey protein concentrate
containing substantially all the heat labile whey protein present
in the raw milk, said whey protein concentrate having
immunoenhancing properties that are heat labile, insensitive to
pancreatic digestion and dependent upon the undenatured state and
being present in an amount substantially sufficient to supplement
requirements of protein of said mammal.
58. A use of a whey protein composition for improving immune
response in mammals, wherein the whey protein concentrate
comprises a mixture having two or more proteins of whey.
59. A whey protein composition for improving immune response,
wherein the whey protein concentrate comprises a substantially
undenatured whey protein isolate mixture which is cystine rich and
rich in glutamyl cysteine, in an amount effective to replenish
depleted cellular glutathione and enhance the immune response.
60. Use of a whey protein composition for improving the immune
response in
mammals, wherein the whey protein concentrate comprises a
substantially undenatured whey protein isolate mixture which is
cystine rich and rich in glutamyl cysteine, in an amount effect to
replenish depleted cellular glutathione and enhance the immune
response.
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